BIS-TRIS PROPANE [1,3-BIS[TRIS(HYDROXYMETHYL)METHYLAMINO] PROPANE]

BIS-TRIS PROPANE

PRODUCT IDENTIFICATION

CAS NO.

64431-96-5

BIS-TRIS PROPANE

EINECS NO. 264-899-3

FORMULA CH₂[CH₂NHC(CH₂OH)₃]₂

MOL WT. 282.33

H.S. CODE

TOXICITY

SYNONYMS

1,3-Bis[tris(Hydroxymethyl)methylamino]-Propane;

2,2'-(Propane-1,3-diyldiimino)bis[2-(hydroxymethyl)propane-1,3-diol];

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder

MELTING POINT 164 - 165 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Soluble

AUTOIGNITION

VAPOR DENSITY

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Buffer is a substance, generally a solution, that can keep its pH constant, despite the addition of strong acids or strong bases and external influences of temperature, pressure, volume, redox potential. Buffer prevents change in the concentration of another chemical substance, e.g., proton donor and acceptor systems that prevent marked changes in hydrogen ion concentration (pH). Many acid-base reactions take place in living organisms. However, for organisms to perform certain vital functions, the body fluids associated with these functions must maintain a constant pH. For example, blood must maintain a pH of close to 7.4 in order to carry oxygen from the lungs to cells; blood is therefore a powerful buffer. The commonest buffer in chemical solution systems is the acid-base buffer.

Bicarbonate buffer; a buffer system composed of bicarbonate ions and dissolved carbon dioxide; in the body, this system is an important factor in determining the pH of the blood as the concentration of bicarbonate ions is regulated by the kidneys and of carbon dioxide by the respiratory system.
Cacodylate buffer; one containing an organic arsenical salt, used in preparing fixatives for electron microscopy.
Phosphate buffer, a buffer system composed of KH₂PO₄ and Na₂HPO₄; in the body, it is important in regulating the pH of the renal tubular fluids; when 0.025 molal (equimolal of the potassium and sodium salts), the pH is 6.865 at 25 C.
Protein buffer, a buffer system involving proton donor and proton acceptor groups of the amino acid residues of proteins.
TRIS buffer (tromethamine): an amine base used intravenously as an alkalizer for the correction of metabolic acidosis. The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per C temperature decrease, and decreases 0.03-0.05 unit per ten-fold dilution.
Veronal buffer; a barbital buffer commonly used in the preparation of fixatives for electron microscopy.

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

99.0% min

MELTING POINT

164 - 165 C

WATER

1.0% max

HEAVY METALS

5ppm max

USEFUL pH RANGE

10.4 - 11

4ppm max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION

European Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36

BIOLOGICAL BUFFERS

Buffers	CAS #	Useful pH Range	pKa
N-(2-Acetamido)-2-aminoethanesulfonic acid
ACES	7365-82-4	6.1 - 7.5	6.8
N-(2-(Acetamido)imino)diacetic acid
ADA	26239-55-4	6.0 - 7.2	6.59
2-Amino-2-methyl-1-propanol
AMP	124-68-5	9.0 - 10.5	9.70
2-Amino-2-methyl-1,3-propanediol
AMPD	115-69-5	7.8 - 9.7	8.80
N-(1,1-Dimethyl-2-hydroxyethyl)-3-amino-2-hydroxypropanesulfonic acid
AMPSO	68399-79-1	8.3 - 9.7	9.00
N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid
BES	10191-18-1	6.4 - 7.8	7.09
N,N-Bis(2-hydroxyethyl)glycine
Bicine	150-25-4	7.6 - 9.0	8.3
2,2'-(Propane-1,3-diyldiimino)bis[2-(hydroxymethyl)propane-1,3-diol]
Bis-Tris Propane	64431-96-5	6.3 - 9.5	(1) 6.8, (2) 9.0
2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol
Bis-Tris	6976-37-0	5.8 - 7.2	6.50
2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3- propanediol Hydrochloride
BIS-TRIS HCl	124763-51-5	5.8 - 7.2	6.50
4-(Cyclohexylamino)-1-butanesulfonic acid
CABS	161308-34-5	10.0 - 11.4	10.70
3-(Cyclohexylamino)-1-propanesulfonic acid
CAPS	1135-40-6	9.7 - 11.1	10.40
3-(Cyclohexylamino)-2-hydroxy-1-propanesulfonic acid
CAPSO	73463-39-5	8.9 - 10.3	9.60
2-(Cyclohexylamino)ethanesulfonic acid
CHES	103-47-9	8.6 - 10.0	9.49
3-[N-Bis(hydroxyethyl)amino]-2-hydroxypropanesulfonic acid
DIPSO	68399-80-4	7.0 - 8.2	7.60
4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid
EPPS	16052-06-5	7.3 - 8.7	8.00
N-Glycylglycine
Gly-Gly	556-50-3	7.5 - 8.9	8.20
N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid)
HEPBS	161308-36-7	7.6 - 9.0	8.30
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
HEPES	7365-45-9	6.8 - 8.2	7.55
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid Hemisodium salt
HEPES Hemisodium	103404-87-1	6.8 - 8.2	7.55
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid Potassium salt
HEPES potassium	82207-62-3	6.8 - 8.2	7.55
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid Sodium salt Hydrate
HEPES Sodium Hydrate	75277-39-3	6.8 - 8.2	7.5
Imidazole
Imidazole	288-32-4	6.2 - 7.8
2-(4-Morpholino)ethanesulfonic acid
MES	4432-31-9	5.5 - 6.7	6.2
2-(4-Morpholino)ethanesulfonic acid Sodium salt
MES sodium	71119-23-8	5.5 - 6.7	6.2
MOBS	115724-21-5	6.9 - 8.3	7.60
3-N-Morpholino propansulfonic acid
MOPS	1132-61-2	6.5 - 7.9	7.2
3-N-Morpholino propansulfonic acid Hemisodium salt
MOPS Hemisodium	117961-20-3	6.5 - 7.9	7.2
3-N-Morpholino propansulfonic acid Sodium salt
MOPS Sodium	71119-22-7	6.5 - 7.9	7.2
3-Morpholino-2-hydroxypropanesulfonic acid
MOPSO	68399-77-9	6.2 - 7.6	6.90
Piperazine-N,N'-bis(2-ethanesulfonic acid)
PIPES	5625-37-6	6.1 - 7.5	6.8
Piperazine-N,N'-bis(2-ethanesulfonic acid) Dipotassium salt
PIPES Dipotassium	108321-27-3	6.1 - 7.5	6.8
Piperazine-N,N'-bis(2-ethanesulfonic acid) Disodium salt
PIPES Disodium	76836-02-7	6.1 - 7.5	6.8
Piperazine-N,N'-bis(2-hydroxypropanesulfonic acid
POPSO	68189-43-5	7.2 - 8.5	7.80
N-Tris(Hydroxymethyl)methyl-4-aminobutanesulfonic acid
TABS	54960-65-5	8.2 - 9.6	8.90
N-(Tris(hydroxymethyl)methyl)-3-aminopropanesulfonic acid
TAPS	29915-38-6	7.7 - 9.1	8.40
N-[Tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid
TAPSO	68399-81-5	7.0 - 8.2	7.60
Triethanolamine
TEA	102-71-6	7.3 - 8.3	7.80
N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid
TES	7365-44-8	6.8 - 8.2	7.40
N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid hemisodium salt
TES hemisodium		6.8 - 8.2	7.5
N-(Tris(hydroxymethyl)methyl)glycine
Tricine	5704-04-1	7.4 - 8.8	8.2
Tris(hydroxymethyl)methylamine
Tris	77-86-1	7.0 - 9.1	8.06
Tris(hydroxymethyl)methylamine acetate
Tris Acetate	6850-28-8	7.0 - 9.01	8.06
Tris(hydroxymethyl)methylamine Hydrochloride
Tris Hydrochloride	1185-53-1	7.0 - 9.01	8.06

PRICES